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Flow‐Assisted Synthesis: A Key Fragment of SR 142948A
Author(s) -
Kitching Matthew O.,
Dixon Olivia E.,
Baumann Marcus,
Baxendale Ian R.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700904
Subject(s) - chemistry , flow chemistry , hydrazine (antidepressant) , flow (mathematics) , fragment (logic) , combinatorial chemistry , key (lock) , neurotensin , process engineering , nanotechnology , organic chemistry , chromatography , catalysis , computer science , algorithm , mechanics , engineering , biochemistry , physics , receptor , computer security , materials science , neuropeptide
We report a series of multi‐step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine through a short and efficient route.