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High‐Pressure‐Promoted Multicomponent and Metal‐Free Synthesis of Polyfunctionalized Biaryls
Author(s) -
Minuti Lucio,
Piazzolla Francesca,
Temperini Andrea
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700898
Subject(s) - chemistry , metal , component (thermodynamics) , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , thermodynamics , physics
An efficient and metal‐free synthesis of biaryls and heterobiaryls has been developed through a key three‐component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal‐uncontamined 1,1′‐biaryls and heterobiaryls in an energy‐ and step‐economic fashion.