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Rhodium‐Catalyzed Directing‐Group‐Assisted Aldehydic C–H Arylations with Aryl Halides
Author(s) -
Rao Maddali L. N.,
Ramakrishna Boddu S.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700881
Subject(s) - chemistry , rhodium , aryl , regioselectivity , halide , catalysis , aldehyde , combinatorial chemistry , organic chemistry , functional group , medicinal chemistry , alkyl , polymer
A rhodium‐catalyzed general protocol for the directing‐group‐assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy‐ or amino‐group‐directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2‐hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo‐ and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3‐salicyloylpyridines in high yields.