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Integrated Micro‐Flow Synthesis Based on Photochemical Wolff Rearrangement
Author(s) -
Fuse Shinichiro,
Otake Yuma,
Nakamura Hiroyuki
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700789
Subject(s) - wolff rearrangement , diazo , chemistry , photochemistry , flow chemistry , flow (mathematics) , continuous flow , combinatorial chemistry , organic chemistry , biochemical engineering , catalysis , geometry , mathematics , engineering
The Wolff rearrangement of α‐diazo carbonyl compounds has remained important in organic synthesis since its development more than 115 years ago. The risks involved in handling diazo compounds can be minimized by utilizing micro‐flow technology. In addition, photochemical Wolff rearrangement can be carried out efficiently with the aid of micro‐flow technology. Integrated micro‐flow synthesis is therefore well‐suited to the preparation of α‐diazo carbonyl compounds and their photochemical Wolff rearrangement. This review article summarizes recently reported micro‐flow photochemical Wolff rearrangements and their application in integrated micro‐flow syntheses.