Premium
Modular De novo Synthesis of Unsymmetrical BODIPY Dyes Possessing Four Different Aryl Substituents
Author(s) -
Netz Natalie,
DíezPoza Carlos,
Barbero Asunción,
Opatz Till
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700773
Subject(s) - chemistry , nitrile , pyrrole , aryl , bodipy , glycine , combinatorial chemistry , stereochemistry , organic chemistry , amino acid , biochemistry , alkyl , physics , quantum mechanics , fluorescence
A modular synthesis of unsymmetrical BODIPY dyes based on a [6π] electrocyclization to construct both pyrrole rings is presented. The products carry four aryl moieties in positions 1, 3, 5, and 7, which can be freely selected, as well as optional substitution in positions 2 and 8. The method employs acetophenones, benzaldehydes as well as glycine nitrile or glycine ethyl ester as the key building blocks.