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Synthesis and Evaluation of the Antitumor Properties of a Small Collection of Pt II Complexes with 7‐Deazaadenosine as Scaffold
Author(s) -
D'Errico Stefano,
Borbone Nicola,
Piccialli Vincenzo,
Di Gennaro Elena,
Zotti Andrea,
Budillon Alfredo,
Vitagliano Carlo,
Piccialli Ilaria,
Oliviero Giorgia
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700730
Subject(s) - chemistry , alkyl , moiety , chirality (physics) , platinum , stereochemistry , nucleoside , denticity , combinatorial chemistry , linker , reactivity (psychology) , cisplatin , catalysis , organic chemistry , crystal structure , medicine , chiral symmetry breaking , physics , alternative medicine , pathology , quantum mechanics , chemotherapy , surgery , computer science , nambu–jona lasinio model , operating system , quark
Herein we report on the synthesis and evaluation of the preliminary antitumor properties of a small collection of platinum(II) complexes in which a cisplatin‐like unit is tethered to 7‐deazaadenosine through linear alkyl chains (from two to six carbon atoms) installed at the purine C6 position. The complexation was performed by exploiting the reactivity of the bidentate amino ligands ( R )‐ and ( S )‐2,3‐diaminopropanoic acids (DAPA) attached to the end of the alkyl chain spacer. By varying the length of the alkyl chain and the chirality of the DAPA moiety we obtained 10 novel nucleoside–platinum complexes, the anticancer properties of which have been evaluated against the A549 and Cal27 human cancer cell lines.