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Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase
Author(s) -
Xu Xingjun,
Kim HyeSun,
Chen WeiMin,
Ma Xiang,
Correy Galen J.,
Banwell Martin G.,
Jackson Colin J.,
Willis Anthony C.,
Carr Paul D.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700705
Subject(s) - chemistry , amaryllidaceae alkaloids , acetylcholinesterase , alkaloid , amaryllidaceae , stereochemistry , enzyme , organic chemistry , botany , biology
The title alkaloids, 1 and 2 , have been prepared using cross‐coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, it was found that biaryl 1 is not a significant inhibitor of this enzyme, and neither are any of its congeners, including alkaloid 2 .