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Linear Selective C–H Bond Alkylation with Activated Olefins Catalyzed by Cp*Co III
Author(s) -
Barsu Nagaraju,
Emayavaramban Balakumar,
Sundararaju Basker
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700696
Subject(s) - alkylation , chemistry , catalysis , alkyl , medicinal chemistry , organic chemistry
A simple and efficient method for Cp*Co III ‐catalyzed C–H bond alkylation using activated olefins was developed. Selective C–H monoalkylation was performed at ambient temperature. One‐pot symmetrical dialkylation and sequential unsymmetrical C–H dialkylation were performed to give the desired products in excellent yields. The reaction was found to proceed through an M–alkyl intermediate after migratory insertion, and this intermediate undergoes protodemetalation to give the expected alkylated product along with the regenerated catalyst.