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A Mechanochemical‐Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles
Author(s) -
Gaspa Silvia,
Porcheddu Andrea,
Valentoni Antonio,
Garroni Sebastiano,
Enzo Stefano,
De Luca Lidia
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700689
Subject(s) - chemistry , organic chemistry , ball mill , aldehyde , primary (astronomy) , solvent , nitrile , mechanochemistry , column chromatography , catalysis , chemical engineering , physics , astronomy , engineering
A mild, efficient, metal‐ and solvent‐free oxidation of primary amines to aldehydes, ketones, and nitriles under ball‐milling conditions is presented. This method has proved to be compatible with various functional groups and only requires easily accessible starting materials. Simple purification of the reaction mixtures by short‐column chromatography afforded pure aldehydes, ketones, and nitriles as products.