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Synthesis of Pyridone Derivatives from 7‐Hydroxy‐7‐polyfluoroalkylhexahydroimidazo[1,2‐ a ]pyridin‐5‐ones
Author(s) -
Goryaeva Marina V.,
Burgart Yanina V.,
Kudyakova Yulia S.,
Ezhikova Marina A.,
Kodess Mikhail I.,
Saloutin Victor I.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700683
Subject(s) - chemistry , 2 pyridone , intramolecular force , cleavage (geology) , alkyl , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , geotechnical engineering , fracture (geology) , engineering
The synthesis of 1‐(2‐aminoethyl)‐6‐alkyl‐4‐polyfluoroalkylpyridin‐2‐ones based on the acidic cleavage of 7‐hydroxy‐7‐polyfluoroalkylhexahydroimidazo[1,2‐ a ]pyridin‐5‐ones is reported. Depending on the reaction conditions, the pyridones can be obtained as bases, salts, acetamides, or the products of intramolecular cyclization, dihydroimidazopyridines. High tuberculostatic activity was observed for some of the synthesized compounds.