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Front Cover: Catalytic Intramolecular Wittig Reaction Based on a Phosphine/Phosphine Oxide Catalytic Cycle for the Synthesis of Heterocycles (Eur. J. Org. Chem. 18/2017)
Author(s) -
Wang Long,
Sun Mei,
Ding MingWu
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700593
Subject(s) - chemistry , wittig reaction , phosphine oxide , phosphine , catalysis , catalytic cycle , intramolecular force , reagent , combinatorial chemistry , medicinal chemistry , organic chemistry
The cover picture shows the catalytic intramolecular Wittig reaction starting from carbonyl‐containing bromides. The byproduct R 3 PO participates in the catalytic cycle; therefore, the Wittig reaction can be accomplished with only a catalytic amount of the organophosphorus reagent. The reaction has also been applied to the efficient and selective synthesis of isoquinolin‐1(2 H )‐ones, indoles, 2,3‐dihydro‐1 H ‐2‐benzazepin‐1‐ones, benzofurans, and 1,2‐dihydroquinolines by using a catalytic amount of phosphine oxide and a tetramethyldisiloxane/titanium isopropoxide reductant system. Details are discussed in the Full Paper by M.‐W. Ding et al. on page 2568 ff (DOI: 10.1002/ejoc.201601628 ).