Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines | Zendy

Shabalin Dmitrii A. | Zendy; Dvorko Marina Yu. | Zendy; Zolotareva Evgeniya E. | Zendy; Ushakov Igor' A. | Zendy; Vashchenko Alexander V. | Zendy; Schmidt Elena Yu. | Zendy; Trofimov Boris A. | Zendy

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Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines

Author(s) -

Shabalin Dmitrii A.,

Dvorko Marina Yu.,

Zolotareva Evgeniya E.,

Ushakov Igor' A.,

Vashchenko Alexander V.,

Schmidt Elena Yu.,

Trofimov Boris A.

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201700589

Subject(s) - chemistry , combinatorial chemistry , scope (computer science) , organic chemistry , catalysis , programming language , computer science

An efficient and selective synthesis of 1,4‐dihydropyridazines through the acid‐catalyzed recyclization of 5‐hydroxy‐Δ 1 ‐pyrrolines with hydrazines has been developed. The scope of this reaction was thoroughly explored, resulting in the generation of a library of 1,4‐dihydropyridazines in good to excellent yields (25 examples, 67–100 % yields).

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