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Metal‐Free Selective Synthesis of 1,4‐Dihydropyridazines from Hydroxypyrrolines and Hydrazines
Author(s) -
Shabalin Dmitrii A.,
Dvorko Marina Yu.,
Zolotareva Evgeniya E.,
Ushakov Igor' A.,
Vashchenko Alexander V.,
Schmidt Elena Yu.,
Trofimov Boris A.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700589
Subject(s) - chemistry , combinatorial chemistry , scope (computer science) , organic chemistry , catalysis , programming language , computer science
An efficient and selective synthesis of 1,4‐dihydropyridazines through the acid‐catalyzed recyclization of 5‐hydroxy‐Δ 1 ‐pyrrolines with hydrazines has been developed. The scope of this reaction was thoroughly explored, resulting in the generation of a library of 1,4‐dihydropyridazines in good to excellent yields (25 examples, 67–100 % yields).