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Amides as Weak Coordinating Groups in Proximal C–H Bond Activation
Author(s) -
Das Riki,
Kumar Gangam Srikanth,
Kapur Manmohan
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700546
Subject(s) - chemistry , surface modification , reactivity (psychology) , stereochemistry , metallacycle , combinatorial chemistry , selectivity , catalysis , organic chemistry , medicine , x ray crystallography , alternative medicine , physics , pathology , diffraction , optics
Site selectivity is an inherent challenge in C–H functionalization reactions. The most intensively sought‐after approaches have involved the employment of Lewis‐basic coordinating groups to direct a metal to a proximal site, in the process generating a metallacycle capable of further organometallic reactivity. In the recent years considerable effort has been directed towards the development of new transformations involving transition‐metal‐mediated C–H functionalization directed by weakly coordinating groups. This microreview focuses on the role and utility of amides and anilides in directed, proximal C–H bond functionalization reactions.