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Hydrazone–Cu‐Catalyzed Suzuki–Miyaura‐Type Reactions of Dibromoalkenes with Arylboronic Acids
Author(s) -
Watanabe Kohei,
Mino Takashi,
Hatta Chikako,
Ishikawa Eri,
Yoshida Yasushi,
Sakamoto Masami
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700535
Subject(s) - chemistry , hydrazone , alkyne , catalysis , organic chemistry , benzene , combinatorial chemistry , medicinal chemistry
We have found that Suzuki–Miyaura‐type reactions of dibromoalkenes with arylboronic acids using a hydrazone–Cu catalyst system proceeded smoothly under mild conditions to afford the corresponding internal alkyne derivatives in good yields. Furthermore, we also succeeded in the synthesis of o ‐allyloxy(ethynyl)benzene derivatives, which are known to be effective precursors of various heterocyclic compounds, through this reaction.