Premium
Palladium‐Catalysed Chemo‐ and Regioselective C–H Bond Acylation of Pyridine N ‐Oxides with Benzyl Halides and Alcohols
Author(s) -
Kianmehr Ebrahim,
Gholamhosseyni Maral
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700531
Subject(s) - chemistry , acylation , palladium , halide , regioselectivity , pyridine , organic chemistry , medicinal chemistry , catalysis
A palladium‐catalysed method for the acylation of ortho C–H bonds of pyridine N ‐oxides using readily available benzyl halides and benzyl alcohols as the active acylating agents is described. This procedure provides a new approach to 2‐acylpyridine N ‐oxides, which may be used as precursors for the synthesis of pharmaceuticals and agrochemicals.