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Metal‐Catalyzed Direct C–H Fluoroalkenylation of Pyridine N ‐Oxides and Related Derivatives
Author(s) -
Lehecq Alexis,
Rousée Kevin,
Schneider Cédric,
Levacher Vincent,
Hoarau Christophe,
Pannecoucke Xavier,
Bouillon JeanPhilippe,
CouveBonnaire Samuel
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700505
Subject(s) - catalysis , pyridine , metal , chemistry , organic chemistry
The copper‐ and palladium/copper‐catalyzed direct C–H fluoroalkenylation of pyridine N ‐oxides and related heterocycles using various gem ‐bromofluoroalkenes as electrophiles is reported. The dimetallic palladium/copper process proved to be more efficient than copper catalysis, giving access to various relevant 2‐fluoroalkenylated azines.