Premium
An Efficient Homogenized Ruthenium(II) Pincer Complex for N ‐Monoalkylation of Amines with Alcohols
Author(s) -
Yang FaLiu,
Wang YingHui,
Ni YongFeng,
Gao Xiang,
Song Bing,
Zhu Xinju,
Hao XinQi
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700486
Subject(s) - chemistry , ruthenium , pincer movement , selectivity , catalysis , pyridine , ionic bonding , combinatorial chemistry , medicinal chemistry , hydrogen bond , alkylation , organic chemistry , ion , molecule
An ionic 2,6‐bis(imidazo[1,2‐α]pyridin‐2‐yl)pyridine‐based N^N^N pincer ruthenium(II) complex exhibited high efficiency in the C–N bond formation between amines and alcohols by the “borrowing hydrogen” (BH) or “hydrogen autotransfer” (HA) concept. The synthetic protocol selectively generated monoalkylated amines without formation of tertiary amines during the reaction. The unique selectivity enabled the formation of symmetrically and asymmetrically substituted diamines. This methodology features several advantages including a low catalyst loading (as low as 0.5 mol‐%), a short reaction time (as short as 2 h), and excellent N ‐monoalkylation selectivity.