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Ag I ‐Promoted Difluoromethylation of Isocyanides To Give Difluoromethylated Phenanthridines
Author(s) -
Wan Wen,
Xu Xiaochen,
Chen Yunrong,
Jiang Haizhen,
Wang Yong,
Deng Hongmei,
Hao Jian
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700470
Subject(s) - chemistry , homolysis , isocyanide , medicinal chemistry , electrophilic aromatic substitution , radical , radical cyclization , substitution (logic) , combinatorial chemistry , organic chemistry , computer science , programming language
An Ag I ‐mediated ethoxycarbonyldifluoromethylation of isocyanides has been developed. This radical cascade reaction involves the addition of difluoromethylene radical to the isocyanide functionality, and subsequent homolytic aromatic substitution to give difluoromethylated phenanthridines with a good functional‐group tolerance.