Straightforward and Stereoselective Synthesis of α,β‐Diamino Acid Derivatives by Means of an Organocatalyzed Decarboxylative Mannich Reaction | Zendy

Singjunla Yuttapong | Zendy; Baudoux Jérôme | Zendy; Rouden Jacques | Zendy

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Straightforward and Stereoselective Synthesis of α,β‐Diamino Acid Derivatives by Means of an Organocatalyzed Decarboxylative Mannich Reaction

Author(s) -

Singjunla Yuttapong,

Baudoux Jérôme,

Rouden Jacques

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201700468

Subject(s) - chemistry , dabco , stereoselectivity , diastereomer , organic chemistry , mannich reaction , octane , organocatalysis , malonic acid , enantioselective synthesis , catalysis

A rapid and convenient method has been developed for the stereoselective synthesis of α,β‐diamino acid derivatives from amido‐substituted malonic acid half oxyesters (MAHOs) and imines. The anti products were obtained with a diastereomeric ratio up to 99:1 by using a decarboxylative Mannich reaction catalyzed by commercially available 1,4‐diazabicyclo[2.2.2] octane (DABCO).

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