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α,α‐Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1‐Diarylethenes and α,α‐Diaryl Acetaldehydes
Author(s) -
Tiwari Praveen Kumar,
Sivaraman Balasubramaniam,
Aidhen Indrapal Singh
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700467
Subject(s) - chemistry , reagent , amide , glycolic acid , bromide , organic chemistry , grignard reaction , combinatorial chemistry , grignard reagent , molecule , lactic acid , biology , bacteria , genetics
Towards assembling of diarylmethine unit present in biologically important molecules, we have developed a new Weinreb Amide (WA) based building block derived from glycolic acid. The WA functionality present in this building block permits the sequential addition of various arylmagnesium bromide reagents in a controlled manner that enables assembly of a diarylmethine unit. The developed synthetic route provides easy access to important diarylethenes and α,α‐diarylethylene glycols. The synthesized α,α‐diarylethylene glycols provide access to synthetically important symmetrical and unsymmetrical α,α‐diaryl acetaldehydes as valuable intermediates.