Enantioselective Mannich Reaction Employing 1,3,5‐Triaryl‐1,3,5‐triazinanes Catalyzed by Chiral‐at‐Metal Rhodium Complexes | Zendy

Gong Jun | Zendy; Li ShiWu | Zendy; Qurban Saira | Zendy; Kang Qiang | Zendy

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Enantioselective Mannich Reaction Employing 1,3,5‐Triaryl‐1,3,5‐triazinanes Catalyzed by Chiral‐at‐Metal Rhodium Complexes

Author(s) -

Gong Jun,

Li ShiWu,

Qurban Saira,

Kang Qiang

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201700463

Subject(s) - enantioselective synthesis , chemistry , rhodium , mannich reaction , catalysis , yield (engineering) , adduct , metal , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , metallurgy

Chiral‐at‐metal Rh III complexes catalyze the efficient enantioselective Mannich reaction of 2‐acyl imidazoles with 1,3,5‐triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol‐% of Rh III complex on gram scale without any loss in enantioselectivity.

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