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Enantioselective Mannich Reaction Employing 1,3,5‐Triaryl‐1,3,5‐triazinanes Catalyzed by Chiral‐at‐Metal Rhodium Complexes
Author(s) -
Gong Jun,
Li ShiWu,
Qurban Saira,
Kang Qiang
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700463
Subject(s) - enantioselective synthesis , chemistry , rhodium , mannich reaction , catalysis , yield (engineering) , adduct , metal , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , metallurgy
Chiral‐at‐metal Rh III complexes catalyze the efficient enantioselective Mannich reaction of 2‐acyl imidazoles with 1,3,5‐triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol‐% of Rh III complex on gram scale without any loss in enantioselectivity.