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KO t Bu‐Mediated Domino Isomerization and Functionalization of Aromatic Allylic Alcohols
Author(s) -
Suchand Basuli,
Satyanarayana Gedu
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700440
Subject(s) - chemistry , isomerization , allylic rearrangement , electrophile , domino , alkylation , ligand (biochemistry) , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , biochemistry , receptor
Transition‐metal‐ as well as ligand‐free base‐mediated domino isomerization and alkylation of allylic alcohols is presented. This protocol features the conversion of simple allylic alcohols into the corresponding ketones through isomerization in the presence of a simple base. Significantly, these in situ generated ketones subsequently undergo alkylation with styrenes as electrophiles, in a domino one‐pot fashion, as an atom‐ and step‐economical chemical process.