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Metal‐Free trans ‐Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone
Author(s) -
Gopalan Greeshma,
Dhanya Bhandara Purayil,
Saranya Jayaram,
Reshmitha Thankappan Remadevi,
Baiju Thekke Veettil,
Meenu Murugan Thulasi,
Nair Mangalam S.,
Nisha Prakasan,
Radhakrishnan Kokkuvayil Vasu
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700410
Subject(s) - aziridine , chemistry , combinatorial chemistry , in vitro , organic chemistry , stereochemistry , biochemistry , ring (chemistry)
Herein, we describe a metal‐free, iodosobenzene diacetate mediated trans ‐aziridination of zerumbone by the direct use of sulfonamides. Preliminary in vitro screening showed that the synthesized compounds had better antiproliferative and antidiabetic activities than the parent compound zerumbone.