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Three‐Component Coupling Reaction in Water: A One‐Pot Protocol for the Construction of P–S–C(sp 3 ) and P–Se–C(sp 3 ) Bonds
Author(s) -
Zhang Xinghua,
Shi Zheng,
Shao Changwei,
Zhao Jinlong,
Wang Dungai,
Zhang Gaoqi,
Li Liang
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700344
Subject(s) - chemistry , selenium , halide , substrate (aquarium) , coupling reaction , sulfur , alkyl , component (thermodynamics) , coupling (piping) , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , oceanography , geology , mechanical engineering , physics , engineering , thermodynamics
A one‐pot, three‐component coupling reaction of primary alkyl halides (or tosylates), elemental sulfur/selenium, and P(O)–H compounds in water was developed. This procedure affords valuable phosphorothioates/phosphoroselenoates, including P‐chiral compounds, with broad substrate scope and high efficiency. Moreover, this facile protocol can be applied to gram‐scale preparations.