Front Cover: Sphaericin, a Lasso Peptide from the Rare Actinomycete Planomonospora sphaerica (Eur. J. Org. Chem. 8/2017)

The cover picture shows the three‐dimensional solution structure of a new lasso peptide sphaericin. Lasso peptides are a class of natural occurring peptides, which possess an isopeptide bond and a common knot structural motif. The uniqueness of a lasso peptide is the three‐dimensional structure with a tail part that forms a loop through its own ring. A new lasso peptide named sphaericin was isolated as an antibacterial principle from the rare actinomycete Planomonospora sphaerica . Calculations based on NOE experiments revealed that sphaericin possesses a typical lasso‐peptide fold with a ring, a loop, and a tail. Details are discussed in the Full Paper by S. Kodani et al. on page 1177 ff (DOI: 10.1002/ejoc.201601334 ).