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Copper‐Mediated [(Diethylphosphono)difluoromethyl]thiolation of α‐Bromo Ketones
Author(s) -
Ivanova Maria V.,
Bayle Alexandre,
Besset Tatiana,
Pannecoucke Xavier,
Poisson Thomas
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700182
Subject(s) - chemistry , nucleophile , combinatorial chemistry , copper , ketone , nucleophilic addition , organic chemistry , catalysis
We report herein a straightforward access to α‐[(diethoxyphosphoryl)difluoromethyl]thiolated ketones. The methodology, which involves the nucleophilic [Cu]CF 2 PO(OEt) 2 species, has allowed the formation of the targeted compounds in moderate to high yields by using a simple procedure. This method represents a convenient alternative to the known approaches for the introduction of this emergent fluorinated motif.