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Copper‐Catalyzed Multicomponent Reactions: Synthesis of Fused 1,2,3‐Triazolo‐1,3,6‐triazonines
Author(s) -
Peringer Fernando,
Nascimento José Edmilson R.,
Abib Paola B.,
Barcellos Thiago,
Eycken Erik V.,
Perin Gelson,
Jacob Raquel G.,
Alves Diego
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700170
Subject(s) - chemistry , copper , catalysis , iodide , combinatorial chemistry , base (topology) , reaction conditions , organic chemistry , mathematical analysis , mathematics
We describe our results on the synthesis of fused 1,2,3‐triazolo‐1,3,6‐triazonines through a copper‐catalyzed multicomponent reaction. The products were obtained in moderate to excellent yields by the reaction of 2‐azidobenzaldehydes, substituted diaminobenzenes and a range of terminal alkynes in the presence of a catalytic amount of copper iodide, with Et 3 N as base, in DMSO at 100 °C. This method proved to be efficient for the combinatorial synthesis of new medium‐sized N‐heterocyclic rings with potential applications in biological studies.