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Ruthenium‐Catalyzed Cross‐Metathesis of Allyl Acetate and Styrenes: A Practical Approach to the Synthesis of Tripolinolate A and Its Analogs
Author(s) -
Araki Yasuhiro,
Topolovčan Nikola,
Kotora Martin
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700132
Subject(s) - chemistry , ruthenium , metathesis , catalysis , organic chemistry , combinatorial chemistry , polymerization , polymer
The scope of the Ru‐catalyzed cross‐metathesis of allyl acetates and styrenes was explored. A variety of electronically and structurally divergent styrenes were tolerated, and the resultant products were obtained in reasonable yields. The reported method was utilized in the synthesis of inhibitors of the proliferation of glioma and colorectal cancer cells, tripolinolate A and its diacetate analog.