Premium
Front Cover: Engineering Molecular Topology: A Pseudopeptidic Macrocyclic Figure‐Eight Motif (Eur. J. Org. Chem. 7/2017)
Author(s) -
Sharma Sakshi,
Thorat Shridhar H.,
Gonnade Rajesh G.,
Jasinski Jerry P,
Butcher Ray,
Haridas V.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700131
Subject(s) - chemistry , front cover , motif (music) , cover (algebra) , stereochemistry , topology (electrical circuits) , molecular engineering , organic chemistry , combinatorics , physics , engineering , mechanical engineering , mathematics , acoustics
The cover picture shows the structure of a pseudopeptidic macrocycle. The 32‐membered macrocycle containing four leucine residues, two phenyl rings, and two bispidine units adopts a figure‐eight topology. The turn units in the structure required to form the figure‐eight topology are provided by bispidine and 1,3‐benzenedicarbonyl linkers. A strategy for the design and synthesis of macrocycles with intriguing topology was developed, which was demonstrated by the synthesis of two macrocycles, one with an open cavity and one with a figure‐eight topology. Details are discussed in the Communication by V. Haridas et al. on page 1120 ff (DOI: 10.1002/ejoc.201601365 ).