Premium
Addition of Primary Amines to 2‐(1‐Alkynyl)‐2‐cycloalken‐1‐ones
Author(s) -
Urbanaitė Aurelija,
Šteinys Lukas,
Brukštus Algirdas,
Čikotienė Inga
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700119
Subject(s) - chemistry , primary (astronomy) , cycloalkene , stereoselectivity , nucleophile , double bond , medicinal chemistry , organic chemistry , stereochemistry , catalysis , physics , astronomy
The regio‐ and stereoselective nucleophilic addition of primary aliphatic amines to 2‐(1‐alkynyl)‐2‐alken‐1‐ones was found to proceed through double‐bond migration. In particular, this is a mild and atom‐economical route for the preparation of ( Z )‐β‐enaminones having cycloalkene rings.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom