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Addition of Primary Amines to 2‐(1‐Alkynyl)‐2‐cycloalken‐1‐ones
Author(s) -
Urbanaitė Aurelija,
Šteinys Lukas,
Brukštus Algirdas,
Čikotienė Inga
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700119
Subject(s) - chemistry , primary (astronomy) , cycloalkene , stereoselectivity , nucleophile , double bond , medicinal chemistry , organic chemistry , stereochemistry , catalysis , physics , astronomy
The regio‐ and stereoselective nucleophilic addition of primary aliphatic amines to 2‐(1‐alkynyl)‐2‐alken‐1‐ones was found to proceed through double‐bond migration. In particular, this is a mild and atom‐economical route for the preparation of ( Z )‐β‐enaminones having cycloalkene rings.