Base‐Mediated Domino Reaction of ortho ‐Carbonylated Alkynyl‐Substituted Arenealdehydes with Indoles: Access to Indole‐Functionalized Isobenzofurans

A base‐mediated domino reaction of ortho ‐carbonylated alkynyl‐substituted arenealdehydes with indoles has been developed, and a variety of indolyl‐substituted isobenzofuran derivatives can be rapidly obtained in high yields. Notably, the selective N ‐alkylation of indoles and 5‐ exo ‐ dig cyclization of alkynes can be achieved efficiently to give N ‐functionalized products. This reaction involves a domino procedure for the formation of two bonds under simple conditions and has a broad substrate scope.