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Direct Regioselective Alkylation of Non‐Basic Heterocycles with Alcohols and Cyclic Ethers through a Dehydrogenative Cross‐Coupling Reaction under Metal‐Free Conditions
Author(s) -
Kianmehr Ebrahim,
Fardpour Maryam,
Khan Khalid Mohammed
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201700030
Subject(s) - chemistry , regioselectivity , alkylation , peroxide , metal , organic chemistry , coupling reaction , combinatorial chemistry , catalysis
A metal‐free, simple, and highly efficient method for the direct alkylation of non‐basic heterocycles and basic ones with various alcohols and cyclic ethers has been developed based on an oxidative C–H activation process. The corresponding products were generated through a dehydrogenative C–C cross‐coupling reaction in the presence of di‐ tert ‐butyl peroxide in good to high yields.