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Front Cover: Pathways for the Reactions Between Neurotoxic Organophosphorus Compounds and Oximes or Hydroxamic Acids (Eur. J. Org. Chem. 35/2016)
Author(s) -
Bierwisch Anne,
Koller Marianne,
Worek Franz,
Kubik Stefan
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201670351
Subject(s) - chemistry , hydroxamic acid , nucleophile , tabun , front cover , nerve agent , organic chemistry , combinatorial chemistry , catalysis , cover (algebra) , enzyme , mechanical engineering , engineering , acetylcholinesterase
The cover picture shows that the reaction between a hydroxamic acid and the chemical warfare agent tabun leads to phosphorylation of the hydroxamic acid group with concomitant detoxification of the nerve agent. Reaction pathways differ when other organophosphorus compounds are used, or oximes are employed as nucleophiles, but all reactions investigated encompass the consumption of the nucleophile. Thus, it was concluded that oximes and hydroxamic acid are unlikely to afford catalytic scavengers for nerve agents. Details are discussed in the article by S. Kubik et al. on p. 5831 ff .