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Front Cover: A Click Ligation Based on SuFEx for the Metal‐Free Synthesis of Sugar and Iminosugar Clusters (Eur. J. Org. Chem. 30/2016)
Author(s) -
Zelli Renaud,
Tommasone Stefano,
Dumy Pascal,
Marra Alberto,
Dondoni Alessandro
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201670301
Subject(s) - iminosugar , chemistry , sulfonyl , click chemistry , reagent , organic chemistry , context (archaeology) , combinatorial chemistry , polymer chemistry , nucleophile , catalysis , enzyme , paleontology , alkyl , biology
The cover picture shows a stamp celebrating the 100th anniversary of the 1906 Nobel prize, won by the French chemist Henri Moissan for the isolation of fluorine. After its discovery, the fluorine atom became part of many organic reagents, and fluorination played a key role in organic synthesis, drug design, and polymeric‐material production. Recently, Sharpless and co‐workers highlighted sulfonyl fluorides as potential click reagents owing to their easy preparation and purification, high stability under basic conditions, and good reactivity towards C ‐, O ‐, and N ‐nucleophiles (see Angew. Chem. Int. Ed . 2014 , 126 , 9620). In this context, stable sulfonyl fluorides featuring sugar, iminosugar, and calixarene moieties have been prepared and reacted with amines under metal‐free conditions to give monovalent and multivalent sulfonamide derivatives. Details are discussed in the article by A. Marra, A. Dondoni et al. on p. 5102 ff .