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Front Cover: The Amadori Rearrangement for Carbohydrate Conjugation: Scope and Limitations (Eur. J. Org. Chem. 25/2016)
Author(s) -
Hojnik Cornelia,
Müller Anne,
Gloe TobiasElias,
Lindhorst Thisbe K.,
Wrodnigg Tanja M.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201670251
Subject(s) - chemistry , amadori rearrangement , glycosidic bond , carbohydrate chemistry , stereochemistry , carbohydrate , amino acid , combinatorial chemistry , hydrolysis , organic chemistry , biochemistry , enzyme , glycation , receptor
The cover picture shows the Amadori rearrangement, which allows the conjugation of carbohydrate moieties to diverse amino components, such as amino acids, lysine‐containing peptides, complex amino‐functionalized glycosides, as well as di‐ and triamines in one step without protecting‐group manipulations. The linkage through a C ‐glycosidic‐type conjugation, which is not sensitive towards enzymatic or chemical hydrolysis in a physiological environment, leads to versatile building blocks for different applications, in particular for biological investigations. Details are discussed in the article by T. K. Lindhorst, T. M. Wrodnigg et al. on p. 4328 ff .