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Front Cover: 1‐Hydrosilatrane: A Locomotive for Efficient Ketone Reductions (Eur. J. Org. Chem. 2/2017)
Author(s) -
Varjosaari Sami E.,
Skrypai Vladislav,
Suating Paolo,
Hurley Joseph J. M.,
Gilbert Thomas M.,
Adler Marc J.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601660
Subject(s) - chemistry , ketone , front cover , reagent , silane , organic chemistry , alcohol , stereoselectivity , enantiomer , reduction (mathematics) , green chemistry , cover (algebra) , combinatorial chemistry , catalysis , reaction mechanism , engineering , mechanical engineering , geometry , mathematics
The cover picture shows artist Jesse Mai's imagination of the reduction of ketones to alcohols by 1‐hydrosilatrane. The accompanying work describes this mild method for reduction, which makes use of a cheap, safe, easy‐to‐handle, and environmentally friendly silane reducing reagent. The reported results include the conversion of a wide scope of ketones to alcohols, as well as demonstrations of stereoselective reductions: the diastereoselective reduction of (–)‐menthone to (+)‐neomenthol and the reduction of a prochiral ketone to an alcohol with an enantiomeric ratio of 87:13. Details are discussed in the Communication by M. J. Adler et al. on page 229 ff (DOI: 10.1002/ejoc.201601256 ).