Synthesis of Phenanthridines through Palladium‐Catalyzed Cascade Reaction of 2‐Halo‐ N ‐Ms‐arylamines with Benzyl Halides/Sulfonates | Zendy

Yang SiYi | Zendy; Han WenYong | Zendy; Zhang DingLei | Zendy; Zhou XiaoJian | Zendy; Bai Mei | Zendy; Cui BaoDong | Zendy; Wan NanWei | Zendy; Yuan WeiCheng | Zendy; Chen YongZheng | Zendy

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Synthesis of Phenanthridines through Palladium‐Catalyzed Cascade Reaction of 2‐Halo‐ N ‐Ms‐arylamines with Benzyl Halides/Sulfonates

Author(s) -

Yang SiYi,

Han WenYong,

Zhang DingLei,

Zhou XiaoJian,

Bai Mei,

Cui BaoDong,

Wan NanWei,

Yuan WeiCheng,

Chen YongZheng

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201601608

Subject(s) - chemistry , aromatization , palladium , catalysis , halide , combinatorial chemistry , organic chemistry , cascade reaction , nucleophile , nucleophilic substitution

An efficient palladium‐catalyzed nucleophilic substitution/C–H activation/aromatization cascade reaction between readily available 2‐halo‐ N ‐Ms‐arylamines (Ms = methanesulfonyl) and benzyl halides/sulfonates has been described. A wide variety of phenanthridines were synthesized in a one‐pot fashion in moderate to high yields (37–86 %). Notably, this method provides a straightforward, facile approach for the synthesis of phenanthridines. The practicality was further substantiated by successfully carrying out a gram‐scale preparation.

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