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Cyclization of Malonate Derivatives with Iodine(III) Reagents
Author(s) -
Malmedy Florence,
Wirth Thomas
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601587
Subject(s) - chemistry , hypervalent molecule , malonate , reagent , diastereomer , iodine , yield (engineering) , dimethyl malonate , organic chemistry , medicinal chemistry , combinatorial chemistry , enantioselective synthesis , catalysis , materials science , metallurgy
The cyclization of malonate derivatives by using hypervalent iodine(III) reagents is described. In this reaction, double bonds are dioxygenated to give five‐membered lactones in up to 70 % yield with diastereomeric ratios of up to 11:1.
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