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[( para ‐Cymene)Ru(dppp)Cl][PF 6 ]‐Catalysed Stereospecific Synthesis of O ‐Dienyl Esters, and Evaluation of the Anticancer Activity of a Long‐Chain Fatty Acid O ‐Dienyl Ester
Author(s) -
Jena Rajesh K.,
Rajesh Y.,
Mandal Mahitosh,
Bhattacharjee Manish
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601557
Subject(s) - chemistry , stereospecificity , dehydration , p cymene , medicinal chemistry , double bond , organic chemistry , stereochemistry , ruthenium , catalysis , biochemistry
O ‐Dienyl esters are obtained through the regio‐ and stereospecific addition of both aromatic and aliphatic carboxylic acids to terminal propargylic alcohols, with the sequential formation of a carbon–oxygen bond and dehydration, in the presence of [( p ‐cymene)Ru(dppp)Cl][PF 6 ] ( 1 ). Also, the cytotoxicity and anticancer activity of the newly synthesized O ‐dienyl ester ( Z )‐3‐methylbuta‐1,3‐dienyl oleate have been investigated.