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Highly Enantioselective Synthesis of Alkylpyridine Derivatives through a Michael/Michael/Aldol Cascade Reaction
Author(s) -
Meazza Marta,
Potter Michael,
Pitak Mateusz B.,
Coles Simon J.,
Mazzanti Andrea,
Rios Ramon
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601491
Subject(s) - chemistry , enantioselective synthesis , aldol reaction , michael reaction , cascade , pyridine , cascade reaction , organocatalysis , organic chemistry , combinatorial chemistry , catalysis , stereochemistry , chromatography
A method for the synthesis of pyridine derivatives based on a triple cascade reaction catalyzed by chiral secondary amines was developed. The resulting cyclohexenes (three C–C bonds were formed) were obtained in good yields with good diastereoselectivities and excellent enantioselectivities.