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Synthesis of N ‐Arylcarbazoles by Palladium‐Catalyzed Direct C–H Arylation of 2‐(Diarylamino)phenyl Triflates
Author(s) -
Uwa Koji,
Tseng YaYi,
Kamikawa Ken
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601467
Subject(s) - chemistry , amination , palladium , aryl , catalysis , ligand (biochemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry , alkyl
The palladium‐catalyzed direct arylation of a series of 2‐(diarylamino)phenyl triflates was examined. The triflates were first synthesized in moderate to good yields through the CuI‐catalyzed aryl amination of aminophenol and aryl iodides, followed by triflation of the resulting triarylphenols. The thus‐obtained 2‐(diarylamino)phenyl triflates were subjected to direct C–H arylation under Pd catalysis to furnish the corresponding N ‐arylcarbazoles in excellent yields if Josiphos was used as the supporting ligand.