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Nucleophilic 18 F‐Labeling of Spirocyclic Iodonium Ylide or Boronic Pinacol Ester Precursors: Advantages and Disadvantages
Author(s) -
Petersen Ida Nymann,
Kristensen Jesper Langgaard,
Herth Matthias Manfred
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601448
Subject(s) - chemistry , pinacol , ylide , nucleophile , aryl , boronic acid , combinatorial chemistry , organic chemistry , catalysis , alkyl
The field of labeling electron‐rich aryl compounds with nucleophilic [ 18 F]fluoride has recently expanded with radiofluorination strategies that apply boronic esters or spirocyclic iodonium ylides as precursors. Herein, we present a direct comparison of these strategies by using nine chemically diverse model compounds. In general, spirocyclic iodonium ylides outperform the boronic esters.