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Cerium Chloride Catalyzed, 2‐Iodoxybenzoic Acid Mediated Oxidative Dehydrogenation of Multiple Heterocycles at Room Temperature
Author(s) -
Hati Santanu,
Sen Subhabrata
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601419
Subject(s) - dehydrogenation , chemistry , cerium , catalysis , chloride , organic chemistry , combinatorial chemistry
Catalytic cerium chloride was found to activate 2‐iodoxybenzoic acid (IBX) for the oxidative dehydrogenation of tetrahydroisoquinolines, tetrahydro‐β‐carbolines, and thiazolidines to their dehydrogenated and aromatic forms at room temperature in moderate to excellent yields. The robustness of the protocol was demonstrated by scaling up the reactions to multigram quantities.