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Au III ‐Catalyzed Formation of α‐Halomethyl Ketones from Terminal Alkynes
Author(s) -
Xing Yalan,
Zhang Ming,
Ciccarelli Sarah,
Lee John,
Catano Bryant
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601416
Subject(s) - chemistry , indolizine , catalysis , alkyne , terminal (telecommunication) , combinatorial chemistry , medicinal chemistry , organic chemistry , telecommunications , computer science
A Au III ‐catalyzed synthesis of α‐halomethyl ketones from terminal alkynes was developed. This approach features excellent functional group compatibility and good yields for both aromatic and aliphatic terminal alkynes. The resulting α‐halomethyl ketones were used to prepare heterocyclic indolizine structures. The plausible mechanism of the one‐pot reaction is proposed.