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Engineering Molecular Topology: A Pseudopeptidic Macrocyclic Figure‐Eight Motif
Author(s) -
Sharma Sakshi,
Thorat Shridhar H.,
Gonnade Rajesh G.,
Jasinski Jerry P,
Butcher Ray,
Haridas V.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601365
Subject(s) - chemistry , topology (electrical circuits) , folding (dsp implementation) , rational design , nuclear magnetic resonance spectroscopy , molecule , molecular engineering , structural motif , stereochemistry , crystallography , nanotechnology , organic chemistry , materials science , biochemistry , mathematics , combinatorics , electrical engineering , engineering
We herein present a rational‐design strategy for the synthesis of molecules with figure‐eight topology. The design concept is based on the incorporation of turn units in the backbone of the macrocycle. The molecular structures and the folding are studied by X‐ray crystallography and NMR, FT‐IR, and CD spectroscopy.