An Expedient Synthesis of Carbazoles through Potassium  tert ‐Butoxide‐Promoted Intramolecular Direct C–H Bond Arylation | Zendy

Lin Songbo | Zendy; He Xingrui | Zendy; Meng Jinpeng | Zendy; Gu Haining | Zendy; Zhang Peizhi | Zendy; Wu Jun | Zendy

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An Expedient Synthesis of Carbazoles through Potassium tert ‐Butoxide‐Promoted Intramolecular Direct C–H Bond Arylation

Author(s) -

Lin Songbo,

He Xingrui,

Meng Jinpeng,

Gu Haining,

Zhang Peizhi,

Wu Jun

Publication year - 2017

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201601293

Subject(s) - chemistry , intramolecular force , medicinal chemistry , potassium , scavenger , ethylene glycol , radical , organic chemistry

Transition‐metal‐free access to carbazoles was achieved through base‐mediated intramolecular C–C bond formation. Reactions of N ‐substituted o ‐halodiarylamines with potassium tert ‐butoxide in the presence of ethylene glycol or 1,10‐phenanthroline provided carbazoles in moderate to excellent yields. This transformation may proceed through a radical pathway according to a control experiment with a radical scavenger.

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