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Diastereoselective Intramolecular Cyanoamidation with Alkenes
Author(s) -
Dreis Ashley M.,
Otte Sadie C.,
Eastwood Matthew S.,
Alonzi Elizabeth R.,
Brethorst Jason T.,
Douglas Christopher J.
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601283
Subject(s) - stereocenter , intramolecular force , chemistry , alkene , stereochemistry , molecule , quaternary carbon , intramolecular reaction , combinatorial chemistry , chirality (physics) , enantioselective synthesis , organic chemistry , catalysis , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
Reported herein is a diastereoselective intramolecular alkene cyanoamidation, wherein high d.r. values are imparted by chiral directing groups. Lactams with an α‐all‐carbon quaternary stereocenter are readily synthesized, which may enable access to structures frequently found in biologically active molecules and natural products.