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Convenient Synthesis of Thieno[3,2‐ b ]indoles and Thieno[3,4‐ b ]indoles by Sequential Site‐Selective Suzuki and Double C–N Coupling Reactions
Author(s) -
Pham Ngo Nghia,
Parpart Silvio,
Grigoryan Sevak,
Ngo Thang Ngoc,
Dang Tuan Thanh,
Ghochikyan Tariel V.,
Saghyan Ashot S.,
Ehlers Peter,
Langer Peter
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601281
Subject(s) - chemistry , suzuki reaction , stereochemistry , combinatorial chemistry , coupling reaction , indole test , organic chemistry , palladium , catalysis
A convenient synthesis of thieno[3,2‐ b ]indoles and thieno[3,4‐ b ]indoles has been developed. The protocol involves a site‐selective Suzuki reaction, followed by a double C–N coupling reaction using anilines, benzylamines, or alkylamines. The yields range from good to excellent.