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Four‐Component Reaction for the Synthesis of Indolizines by Copper‐Catalyzed Aerobic Oxidative Dehydrogenative Aromatization
Author(s) -
Xu Juanfang,
Hu Huayou,
Liu Yun,
Wang Xiang,
Kan Yuhe,
Wang Chao
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601272
Subject(s) - aromatization , chemistry , catalysis , indolizine , dehydrogenation , oxidative phosphorylation , organic chemistry , copper , combinatorial chemistry , biochemistry
A one‐pot, four‐component reaction was developed for the synthesis of indolizines from pyridines, α‐halide carbonyl compounds, primary amines, and maleic anhydride. The key step in this reaction involved the copper‐catalyzed aerobic oxidative aromatization of a tetrahydrogen–indolizine intermediate. Oxygen gas was employed as a clean oxidant to facilitate the catalytic process. Notably, this transformation used readily available starting materials, exhibited broad substrate scope, was easy to handle, and required mild reaction conditions.