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A Pyridinium–Urea‐Coupled Polyether Receptor for the Selective Sensing of Lysine and Cell Imaging
Author(s) -
Ghosh Kumaresh,
Tarafdar Debojyoti,
Petsalakis Ioannis D.,
Theodorakopoulos Giannoula
Publication year - 2017
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201601203
Subject(s) - chemistry , lysine , pyridinium , fluorophore , fluorescence , receptor , urea , amino acid , stereochemistry , biochemistry , organic chemistry , physics , quantum mechanics
The pyridinium‐based polyether‐tethered receptor 1 with a naphthalene fluorophore has been established as a fluororeceptor for the selective sensing of lysine over a series of other amino acids. The receptor 1 exhibits significantly increased fluorescence intensity upon interaction with lysine in CH 3 CN/H 2 O [4:1 v/v, pH 7.4, 10 m m 4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid (HEPES) buffer]. In contrast, the model compound 2 , which is devoid of a polyether unit, interacts with both lysine and valine and shows emission changes at different wavelengths. Receptor 1 was successfully applied for the detection of lysine in the cellular environment through fluorescent imaging.